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Human papillomaviruses and cancer in Uganda.
Newton, R; Bousarghin, L; Ziegler, J; Casabonne, D; Beral, V; Mbidde, E; Carpenter, L; Parkin, D M; Wabinga, H; Mbulaiteye, S; Jaffe, H; Touzé, A; Coursaget, P.
Afiliación
  • Newton R; Cancer Research UK, Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK. Rob.Newton@cancer.org.uk
Eur J Cancer Prev ; 13(2): 113-8, 2004 Apr.
Article en En | MEDLINE | ID: mdl-15100577
In a case-control study in Uganda, we examined associations between different cancer sites or types in relation to antibodies against human papillomaviruses (HPV)-16, -18 and -45. For each cancer site or type, the control group comprised all other cancers excluding those known, or thought to be associated with HPV infection (cancers of the uterine cervix, penis and eye). Among controls the seroprevalence of antibodies was 11% (68/616) against HPV-16, 5% (29/605) against HPV-18 and 6% (35/605) against HPV-45. Antibodies against HPV-16 were significantly associated with only two cancers: uterine cervix [prevalence of antibodies 27% (51/191); odds ratio (OR) 2.0, 95% confidence interval (CI) 1.2-3.1, P=0.01] and penis [prevalence of antibodies 27% (4/15); OR 6.4, 95% CI 1.7-24.3, P=0.01]. For both cancers, the risk increased with increasing anti-HPV-16 antibody titre (Ptrend=0.01 for each). No cancer site or type was significantly associated with antibodies against HPV-18 and -45.
Asunto(s)
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias del Pene / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2004 Tipo del documento: Article
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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Papillomaviridae / Neoplasias del Pene / Neoplasias del Cuello Uterino / Infecciones por Papillomavirus Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa Idioma: En Revista: Eur J Cancer Prev Asunto de la revista: NEOPLASIAS / SAUDE PUBLICA Año: 2004 Tipo del documento: Article