Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.
Bioorg Med Chem Lett
; 14(11): 2931-4, 2004 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-15125962
ABSTRACT
Statine-based inhibitors of Plasmepsin II (PLMII) coupled with Primaquine have been designed using the 'double-drug' approach. The IC50 values for PLMII inhibition ranged from 0.59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
/
Primaquina
/
Inhibidores de Proteasas
/
Ácido Aspártico Endopeptidasas
/
Aminoácidos
/
Antimaláricos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia