Quantitative electroencephalography in frontotemporal dementia with methylphenidate response: a case study.
Clin EEG Neurosci
; 35(2): 108-11, 2004 Apr.
Article
en En
| MEDLINE
| ID: mdl-15164821
Frontotemporal dementia is an underdiagnosed illness with predominant behavioral and executive manifestations. Historically, diagnosis has been based on a combination of clinical history, neuropsychological testing, and brain imaging. No effective treatment currently exists for this disorder. A case is presented using quantitative EEG with methylphenidate challenge correlated with SPECT. The patient underwent neuropsychological testing, a SPECT brain study, and a quantitative EEG, which was repeated after methylphenidate administration. SPECT was significant for hypoperfusion to the bilateral frontotemporal regions, with left-sided hypoperfusion greater than homologous right as demonstrated by LORETA analysis. QEEG correlated with SPECT, and demonstrated profound left greater than right bi-frontotemporal slowing, which normalized partially after methylphenidate administration. The patient has remained on methylphenidate as an outpatient, and has had significant behavioral improvement. Quantitative EEG may provide both diagnostic and therapeutic data with regard to frontotemporal dementia. Further studies of methylphenidate in this population are needed to confirm these data.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mapeo Encefálico
/
Demencia
/
Electroencefalografía
/
Metilfenidato
Límite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Clin EEG Neurosci
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos