Microdomains for dopamine volume neurotransmission in primate prefrontal cortex.
J Neurosci
; 24(23): 5292-300, 2004 Jun 09.
Article
en En
| MEDLINE
| ID: mdl-15190100
ABSTRACT
The explicit yet enigmatic involvement of dopamine in cortical physiology is in part volumetric (beyond the synapse), as is apparently the action of neuroleptics targeting dopamine receptors. The notion that nonsynaptic neuronal membranes would translate extracellular dopamine into receptor-specific spatiotemporal downstream signaling, similar to the chemical synapse, is intriguing. Here, we report that dopamine D5 (but not D1 or D2) receptors in the perisomatic plasma membrane of prefrontal cortical neurons form discrete and exclusively extrasynaptic microdomains with inositol 1,4,5-trisphosphate-gated calcium stores of subsurface cisterns and mitochondria. These findings introduce a novel dopaminoceptive substratum in the brain and a unique D5 receptor-specific signaling paradigm.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dopamina
/
Receptores de Dopamina D1
/
Corteza Prefrontal
/
Transmisión Sináptica
/
Microdominios de Membrana
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos