Structure and function of vertebrate CMP-sialic acid synthetases.
Glycobiology
; 14(10): 43R-51R, 2004 Oct.
Article
en En
| MEDLINE
| ID: mdl-15201214
ABSTRACT
Activation of sugars into nucleotide sugars is critical for their entry into biosynthetic pathways. In eukaryotic cells, the activation of the acidic nine-carbon sugar sialic acid to CMP-sialic acid takes place in the cell nucleus, whereas all other nucleotide sugars are made in the cytoplasm. Molecular cloning of vertebrate CMP-sialic acid synthetases confirmed the nuclear localization and introduced new molecular tools for directly exploring the functional mechanisms of the enzymes, as well as the physiological relevance of their nuclear transport. Although major advances have been made in understanding structure-function relationships and defining elements involved in the nuclear transport, the riddle surrounding the physiological relevance of nuclear localization awaits resolution.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
N-Acilneuraminato Citidililtransferasa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Glycobiology
Asunto de la revista:
BIOQUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Alemania