Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: evidence of two distinct populations.
Fertil Steril
; 58(3): 487-91, 1992 Sep.
Article
en En
| MEDLINE
| ID: mdl-1521640
ABSTRACT
OBJECTIVE:
To investigate the impact of body weight (BW) and insulin levels on gonadotropin and androgen levels in women with the polycystic ovarian syndrome (PCOS).DESIGN:
Comparative study of endocrinologic parameters in PCOS women.SETTING:
University Hospital Reproductive Endocrinology Unit. PATIENTS Thirty obese and 19 nonobese women with PCOS. Seven obese and 7 nonobese normal women. MAIN OUTCOMEMEASURES:
Serum concentrations of insulin, testosterone, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone. Serum LH response to gonadotropin-releasing hormone (GnRH) administration and assessment of insulin resistance by the continuous infusion of glucose with model assessment (CIGMA) test.RESULTS:
Fasting insulin levels correlated with body mass index (BMI). Basal LH levels correlated inversely with BMI. Nonobese women with PCOS had a higher LH response to GnRH than obese women with PCOS. Only obese women with PCOS showed insulin resistance and fasting hyperinsulinemia.CONCLUSIONS:
The data suggest that women with PCOS may be divided into two subgroups those with obesity, insulin resistance, hyperinsulinemia, and normal/minimally elevated LH levels and those with normal BW, elevated LH levels, and normoinsulinemia.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
/
Hormona Luteinizante
/
Insulina
/
Obesidad
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Año:
1992
Tipo del documento:
Article
País de afiliación:
Noruega