The presence of abnormal spermatozoa in the ejaculate: did apoptosis fail?
Hum Fertil (Camb)
; 7(2): 99-103, 2004 Jun.
Article
en En
| MEDLINE
| ID: mdl-15223758
ABSTRACT
With the successful use of Assisted Reproduction, in particular intracytoplasmic sperm injection (ICSI), to treat infertile couples we have become less discriminating with the quality of spermatozoa we use to treat our patients. Numerous studies have shown the presence of nuclear DNA strand breaks in human ejaculated spermatozoa. The reason why human spermatozoa, in particular from men with abnormal semen parameters, possess these abnormalities in their nuclear DNA is still not clear. Two processes that have been linked to the presence of nuclear DNA strand breaks in spermatozoa are anomalies in apoptosis during spermatogenesis or problems in the packaging of the chromatin during spermiogenesis. Understanding the mechanisms responsible for producing abnormal spermatozoa in the human will improve our knowledge about certain causes of male infertility. More importantly, the impact of such sperm, if selected to perform ICSI, needs to be better understood so that any detrimental paternal effects can be avoided.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Espermatozoides
/
Apoptosis
Límite:
Humans
/
Male
Idioma:
En
Revista:
Hum Fertil (Camb)
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos