Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells.
J Clin Invest
; 114(1): 57-66, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15232612
ABSTRACT
Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue receptor (GHS-R), is produced by stomach cells and is a potent circulating orexigen, controlling energy expenditure, adiposity, and growth hormone secretion. However, the functional role of ghrelin in regulation of immune responses remains undefined. Here we report that GHS-R and ghrelin are expressed in human T lymphocytes and monocytes, where ghrelin acts via GHS-R to specifically inhibit the expression of proinflammatory anorectic cytokines such as IL-1beta, IL-6, and TNF-alpha. Ghrelin led to a dose-dependent inhibition of leptin-induced cytokine expression, while leptin upregulated GHS-R expression on human T lymphocytes. These data suggest the existence of a reciprocal regulatory network by which ghrelin and leptin control immune cell activation and inflammation. Moreover, ghrelin also exerts potent anti-inflammatory effects and attenuates endotoxin-induced anorexia in a murine endotoxemia model. We believe this to be the first report demonstrating that ghrelin functions as a key signal, coupling the metabolic axis to the immune system, and supporting the potential use of ghrelin and GHS-R agonists in the management of disease-associated cachexia.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Monocitos
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Linfocitos T
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Citocinas
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Leptina
/
Hormonas Peptídicas
/
Receptores Acoplados a Proteínas G
Límite:
Humans
Idioma:
En
Revista:
J Clin Invest
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos