Timing intrauterine insemination either 33 or 39 hours after administration of human chorionic gonadotropin yields the same pregnancy rates as after superovulation therapy.
Fertil Steril
; 82(1): 13-6, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15236979
ABSTRACT
OBJECTIVE:
To compare a short and long interval between hCG administration and IUI after superovulation for the treatment of infertility.DESIGN:
Prospective, randomized clinical trial.SETTING:
University hospital-based fertility clinic. PATIENT(S) Patients planning superovulation and IUI for the treatment of infertility. INTERVENTION(S) Patients with >or=2 years of infertility enrolled for superovulation and IUI treatment were randomized to IUI after a short (32-34-hour) or long (38-40-hour) interval after hCG injection. Superovulation was accomplished with hMG or recombinant FSH, with dose adjustment until the maturation of two to five follicles, at which time hCG was given. Sperm was prepared with a gradient centrifugation technique, with IUI performed high up in the uterine fundus. MAIN OUTCOME MEASURE(S) Pregnancy rates. RESULT(S) Of the 348 patient cycles randomized, 270 treatment cycles were initiated. Eighty-one initiated cycles were canceled, leaving 189 completed randomized cycles from 75 patients for analysis. Pregnancy rates were not significantly different between groups. There were pregnancies in 20 of the 96 short hCG-IUI interval cycles (21%) and in 14 of the 93 long hCG-IUI interval cycles (15%) (odds ratio = 0.673, 95% confidence interval 0.297-1.518). CONCLUSION(S) Pregnancy rates are the same after superovulation therapy whether IUI is done after a short or a long interval after hCG injection.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Superovulación
/
Inseminación Artificial
/
Índice de Embarazo
/
Gonadotropina Coriónica
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Fertil Steril
Año:
2004
Tipo del documento:
Article
País de afiliación:
Canadá