Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.

Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L; Collins, Margaret S; Rebholz, Sandra; Walzer, Peter D; Cushion, Melanie T

Vanden Eynde, Jean Jacques; Mayence, Annie; Huang, Tien L; Collins, Margaret S; Rebholz, Sandra; Walzer, Peter D; Cushion, Melanie T.

Afiliación

Vanden Eynde JJ; Xavier University of Louisiana, College of Pharmacy, Division of Basic Pharmaceutical Sciences, 1 Drexel Drive, New Orleans 70125, USA.

Bioorg Med Chem Lett ; 14(17): 4545-8, 2004 Sep 06.

Article en En | MEDLINE | ID: mdl-15357989

ABSTRACT

ABSTRACT

A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.

Asunto(s)

Benzamidinas/química; Benzamidinas/uso terapéutico; Pneumocystis carinii/efectos de los fármacos; Neumonía por Pneumocystis/tratamiento farmacológico; Animales; Benzamidinas/farmacología; Pneumocystis carinii/crecimiento & desarrollo; Ratas; Ratas Endogámicas BN; Ratas Long-Evans

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Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neumonía por Pneumocystis / Benzamidinas / Pneumocystis carinii Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2004 Tipo del documento: Article País de afiliación: Estados Unidos

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