Novel bisbenzamidines as potential drug candidates for the treatment of Pneumocystis carinii pneumonia.
Bioorg Med Chem Lett
; 14(17): 4545-8, 2004 Sep 06.
Article
en En
| MEDLINE
| ID: mdl-15357989
ABSTRACT
A series of pentamidine congeners has been synthesized and screened for their in vitro activity against Pneumocystis carinii. Among the tested compounds, bisbenzamidines linked by a flexible pentanediamide or hexanediamide chain (7 and 9) emerged as exceptionally potent agents that were more effective and less toxic than pentamidine in the assays described in this study.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neumonía por Pneumocystis
/
Benzamidinas
/
Pneumocystis carinii
Límite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Estados Unidos