Guillain-Barré syndrome complicating mobilization therapy in a case of B-cell chronic lymphocytic leukemia.
Leuk Lymphoma
; 45(7): 1489-90, 2004 Jul.
Article
en En
| MEDLINE
| ID: mdl-15359655
ABSTRACT
We report a case of Guillain-Barré Syndrome (GBS) which appeared after mobilization therapy in a patient with B-cell chronic lymphocytic leukemia (B-CLL). After obtaining a partial remission with four cycles of fludarabine at standard dose, the patient underwent to high-dose Cytoxan in order to mobilize CD34+ hematopoietic progenitor cells. During neutropenia the patient experienced fever of unknown origin (FUO) and subsequently developed GBS with normalization of his neurologic condition after 2 months. It is possible that a viral-induced activation of an antigen-specific T and B-cell clone caused a local inflammation and toxicity of Schwann cells with demyelination and axonal damage with a self-limited course.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vidarabina
/
Leucemia Linfocítica Crónica de Células B
/
Movilización de Célula Madre Hematopoyética
/
Síndrome de Guillain-Barré
/
Trasplante de Células Madre de Sangre Periférica
Límite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Leuk Lymphoma
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia