Shigella-specific IgA in saliva of children with bacillary dysentery.
FEMS Microbiol Immunol
; 4(2): 65-72, 1992 Jan.
Article
en En
| MEDLINE
| ID: mdl-1547024
ABSTRACT
To study the secretory immune response after Shigella infection, the anti-lipopolysaccharide and anti-Shiga-toxin response in saliva, obtained from children with confirmed shigellosis and healthy children, were determined by enzyme-linked immunosorbent assay and by Western blot. Children with infection showed high titers compared to healthy controls. After Shigella dysenteriae type 1 infection a significant change in titer could be observed in a large number of cases, in contrast to Shigella flexneri infection. It appeared that, in children living in endemic areas, infection with one serotype can give a rise in antibody titer to another serotype. This could be ascribed to polyclonal B cell activation since children in endemic areas routinely show relatively high titers to Shigella antigens. We conclude that the dynamics of salivary anti-Shigella LPS and anti-Shiga-toxin in children with dysentery indicate that it can be applied to studies of immune response in shigellosis for epidemiological and vaccination purposes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Saliva
/
Shigella dysenteriae
/
Shigella flexneri
/
Inmunoglobulina A Secretora
/
Disentería Bacilar
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
FEMS Microbiol Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
Año:
1992
Tipo del documento:
Article
País de afiliación:
Países Bajos