[Expression and significance of PCNA and p27 in benign prostate hypertrophy and prostate carcinoma].
Zhonghua Zhong Liu Za Zhi
; 26(8): 476-8, 2004 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-15555337
ABSTRACT
OBJECTIVE:
To investigate the expression of PCNA and p27 in human benign prostate hypertrophy (BPH) and prostate carcinoma (PCa) and their effect on the genesis and progression of the tumor.METHODS:
The paraffin-embedded sections of 30 cases with BPH and 37 cases with PCa were collected. The expression of p27 and PCNA protein were examined by S-P immunohistochemical method. Comparative analysis for BPH and pathological grade and clinical stage of PCa was performed.RESULTS:
The expression of PCNA in BPH (3.3%) was significantly lower than that in Pca (83.8%, P < 0.01). The expression of p27 in BPH (70.0%) was significantly higher than that in Pca (27.0%, P < 0.05). The expression of p27 was not correlated with histological grade and clinical stage in Pca (P > 0.05). An inverse correlation was found between p27 and PCNA expression in BPH (P < 0.01), while no correlation was found in Pca (P > 0.05).CONCLUSION:
The loss or decreased expression of p27 protein may be related to the genesis of benign prostate hypertrophy, but not to the development of prostate carcinoma; the overexpression of PCNA may play an important role in the malignant behavior and progression of prostate carcinoma.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hiperplasia Prostática
/
Neoplasias de la Próstata
/
Adenocarcinoma
/
Antígeno Nuclear de Célula en Proliferación
/
Proteínas de Ciclo Celular
/
Proteínas Supresoras de Tumor
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Zhong Liu Za Zhi
Año:
2004
Tipo del documento:
Article
País de afiliación:
China