Prediction of response to controlled ovarian hyperstimulation: a comparison of basal and clomiphene citrate-stimulated follicle-stimulating hormone levels.
Fertil Steril
; 57(4): 819-24, 1992 Apr.
Article
en En
| MEDLINE
| ID: mdl-1555694
ABSTRACT
OBJECTIVE:
To test the ovarian reserve in a high-risk population before controlled ovarian hyperstimulation for in vitro fertilization (IVF).DESIGN:
A prospective study comparing the outcome of a clomiphene citrate (CC) challenge test to the outcome of subsequent IVF cycles.SETTING:
Unit for assisted reproductive technology in a university hospital. PATIENTS,PARTICIPANTS:
Ninety-one infertile women with an age of 35 years or more, who had previous ovarian surgery or who had been diagnosed with ovarian endometriosis. MAIN OUTCOMEMEASURE:
Relate follicle-stimulating hormone (FSH) levels before and after CC to frequency of cancellation of an IVF cycle because of a poor follicular response.RESULTS:
Twenty-one patients had elevated basal levels of FSH. Thirty-seven patients, including 20 with high basal levels, showed an excessive FSH response to CC with an FSH level after CC above the 95% confidence limit. Clomiphene citrate-stimulated FSH levels correlated better than basal levels with response to controlled ovarian hyperstimulation. An excessive FSH response to CC predicted a poor response outcome of subsequent controlled ovarian hyperstimulation for IVF with 85% accuracy.CONCLUSION:
Follicle-stimulating hormone response to CC predicts subsequent follicular response to controlled ovarian hyperstimulation.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ovario
/
Fertilización In Vitro
/
Clomifeno
/
Hormona Folículo Estimulante
/
Ciclo Menstrual
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Año:
1992
Tipo del documento:
Article
País de afiliación:
Noruega