Hepatotoxicity of androstenedione in pregnant rats.
Food Chem Toxicol
; 43(2): 341-4, 2005 Feb.
Article
en En
| MEDLINE
| ID: mdl-15621347
ABSTRACT
Androstenedione, a naturally occurring steroid hormone, is a dietary supplement used to enhance athletic performance. Little is known, however, about the safety of its use by young adults including women of child bearing age. To test the possible hepatotoxic effects of androstenedione use, this study was undertaken using a rat model. Pregnant rats (six rats/dose) were exposed to androstenedione in corn oil by gastric intubation at 0, 5, 30 or 60 mg/kg body weight/day beginning 2 weeks before mating and continuing through gestation day 19. On gestation day 20, blood and livers were collected from the pregnant rats for analysis of hepatotoxicity endpoints serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), glutathione (GSH) and glutathione S-transferase (GST), total microsomal P450, nuclear DNA damage and lipid peroxidation. Under these experimental conditions, no significant differences were observed in any of these biomarkers over the concentration range examined.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Androstenodiona
/
Hígado
Límite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Food Chem Toxicol
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos