Timing and nature of wheezing at the endpoint of a bronchial challenge in preschool children.
Pediatr Pulmonol
; 39(3): 262-7, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15668938
ABSTRACT
Bronchial reactivity to inhaled agents in preschool children can be undertaken by auscultating the lungs to detect wheezing, but there is a lack of information on when wheeze first appears at the endpoint of the challenge and on the acoustic characteristics of the wheeze. We recorded breath sounds continuously during tidal breathing inhalation challenges with adenosine 5'-monophosphate, using sensors attached over each upper lobe in 80 preschool children. In 35 children, the challenge was considered positive by a pediatrician who determined the endpoint by detecting wheeze on auscultation after an inhalation. Using acoustic analysis, we determined that the first wheeze appeared during the 2-min period of nebulization in 31% of positive challenges; it was unilateral in 37%, and only inspiratory in 46%. A running window of 6 sec was used to detect at least two wheezes without reference to phase of breathing, and this index had a sensitivity of 97.6% and specificity of 99.7% for determining the endpoint of a challenge. Detecting wheeze acoustically adds safety to the technique by enabling the challenge to be stopped earlier, while the lack of a need to document the phase of breathing simplifies the technique.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pediatría
/
Asma
/
Pruebas de Provocación Bronquial
/
Ruidos Respiratorios
/
Determinación de Punto Final
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pediatr Pulmonol
Asunto de la revista:
PEDIATRIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Israel