Rapid prenatal diagnostics in the interphase nucleus: procedure and cut-off rates.
J Histochem Cytochem
; 53(3): 289-91, 2005 Mar.
Article
en En
| MEDLINE
| ID: mdl-15750004
ABSTRACT
Results of a rapid prenatal aneuploidy screening in uncultured amniocytes using FISH are available within 24 hr. However, care has to be taken of possible pitfalls in connection with the commercially available probe sets and in the interpretation of results in general. Here we present our cut-off rates for and the way in which we handle the Aneu Vysion kit (ABBOTT/Vysis), based on the experience of 1200 studied cases. In summary, the method is reliable, and the risk for misdiagnosis is low ( approximately 0.4%). Nonetheless, the test should be used exclusively as a preamble to full chromosome analysis by microscopy.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Diagnóstico Prenatal
/
Interfase
/
Aneuploidia
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
J Histochem Cytochem
Asunto de la revista:
HISTOCITOQUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Alemania