A morphometric approach for the evaluation of angiogenesis in acute lymphoblastic leukemia of childhood.
Leuk Res
; 29(6): 673-7, 2005 Jun.
Article
en En
| MEDLINE
| ID: mdl-15863208
ABSTRACT
Angiogenesis was estimated in childhood acute lymphoblastic leukemia (ALL) by the use of a novel morphometric method. This was compared with the widely used one of microvessel density (MVD). Bone marrow biopsies were evaluated by immunostaining with anti-Factor VIII related antigen (FVIIIRAg). Angiogenesis was calculated as volume corrected microvessel density index (VC-MVDI), taking into account the bone marrow cellularity. According to our results both MVD and VC-MVDI were increased at diagnosis of ALL in comparison with the control group. However the VC-MVDI increment was not statistically significant. Therefore, VC-MVDI could be more representative of the true increase of angiogenesis, correlating better with the outcome of the disease.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células de la Médula Ósea
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Neovascularización Patológica
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Leuk Res
Año:
2005
Tipo del documento:
Article
País de afiliación:
Grecia