TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence.
Drug News Perspect
; 18(3): 165-71, 2005 Apr.
Article
en En
| MEDLINE
| ID: mdl-15915217
ABSTRACT
The TRPV1 channel is mainly expressed in sensory nerves. Activation of the channel induces neuropeptide release from central and peripheral sensory nerve terminals, resulting in the sensation of pain, neurogenic inflammation, smooth muscle contraction and cough. The TRPV1 channel can be activated by vanilloids such as capsaicin, as well as endogenous stimulators including H(+), heat, lipoxygenase products and anandamide. TRPV1 channel function is upregulated by several endogenous mediators present in inflammatory conditions, which decreases the threshold for activation of the channel. Under these conditions, TRPV1 can be activated by physiological body temperature, slight acidification or lower concentration of TRPV1 agonists. There is evidence that TRPV1 plays a role in the development of pathophysiological changes and symptoms in several diseases. In this review, we discuss TRPV1 channel activation and regulation in normal and diseased conditions, the role of TRPV1 in pain, cough, asthma and urinary incontinence, and the potential use of TRPV1 antagonists as a novel therapy for these diseases.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Dolor
/
Incontinencia Urinaria
/
Tos
/
Canales Iónicos
/
Enfermedades Pulmonares
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug News Perspect
Asunto de la revista:
FARMACOLOGIA
Año:
2005
Tipo del documento:
Article