Patterns of macrolide resistance determinants among S. pyogenes and S. pneumoniae isolates in Saudi Arabia.
J Int Med Res
; 33(3): 349-55, 2005.
Article
en En
| MEDLINE
| ID: mdl-15938596
ABSTRACT
In the study we characterized the macrolide sensitivity of recent clinical isolates of Streptococcus pyogenes and S. pneumoniae collected from major Saudi Arabian hospitals. Susceptibility testing was performed using standard National Committee for Clinical Laboratory Standards methodology on 335 S. pyogenes and 350 S. pneumoniae isolates. Macrolide resistance mechanism phenotypes were identified using double-disk diffusion. All S. pyogenes were penicillin sensitive, while 6.3% were macrolide resistant, the main mechanism of which was of M phenotype (96%). Approximately 51% of S. pneumoniae were penicillin non-susceptible. Macrolide resistance in S. pneumoniae accounted for 18.8%, the majority of which were M phenotype (91%). Low-level resistance mediated by mef-bearing strains pre-dominated. Newer macrolides, including azithromycin, are still considered drugs of choice for empirical treatment of respiratory infection in such circumstances.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Streptococcus pneumoniae
/
Streptococcus pyogenes
/
Pruebas de Sensibilidad Microbiana
/
Farmacorresistencia Bacteriana
/
Farmacorresistencia Bacteriana Múltiple
Tipo de estudio:
Guideline
Límite:
Adult
/
Child
/
Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Int Med Res
Año:
2005
Tipo del documento:
Article
País de afiliación:
Arabia Saudita