Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique.
Biomaterials
; 26(29): 5864-71, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-15949552
ABSTRACT
We have recently developed an organ manufacturing technique that enables us to form cell/biomaterial complex three-dimensional (3D) architectures in designed patterns. This technique employs a highly accurate 3D micropositioning system with a pressue-controlled syringe to deposit cell/biomaterial structures with a lateral resolution of 10 microm. The pressure-activated micro-syringe is equipped with a fine-bore exit needle using which a wide variety of 3D patterns with different arrays of channels (through-holes) were created. The channels can supply living cells with nutrients and allow removing the cell metabolites. The embedded cells remain viable and perform biological functions as long as the 3D structures are retained. The new technology has the potential for eventual high-throughput production of artificial human tissues and organs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Órganos Bioartificiales
/
Ingeniería de Tejidos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Biomaterials
Año:
2005
Tipo del documento:
Article