Neurotrophins in murine viscera: a dynamic pattern from birth to adulthood.
Int J Dev Neurosci
; 23(6): 495-500, 2005 Oct.
Article
en En
| MEDLINE
| ID: mdl-15978771
ABSTRACT
There is growing evidence that target-derived neurotrophins regulate the function of visceral neurons after birth. However, the postnatal profile of neurotrophin supply from internal organs is poorly described. In this study, we compared neurotrophin concentrations in lysates of murine peripheral target tissues (lung, heart, liver, colon, spleen, thymus, kidney and urinary bladder) at different time points after birth. In most organs, there was a decrease of neurotrophin concentrations in the first weeks after birth. In contrast, there were characteristic increases of specific neurotrophins during adolescence or adulthood. These increases were found for nerve growth factor (NGF) in the heart, thymus, kidney and liver, for brain-derived neurotrophic factor (BDNF) in the lung, and for neurotrophin-3 (NT-3) in the colon. In conclusion, we show that neurotrophins display a very differential and dynamic profile in internal organs after birth.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vísceras
/
Envejecimiento
/
Vías Autónomas
/
Factores de Crecimiento Nervioso
Límite:
Animals
Idioma:
En
Revista:
Int J Dev Neurosci
Año:
2005
Tipo del documento:
Article
País de afiliación:
Alemania