Sensory gating in the human hippocampal and rhinal regions.
Clin Neurophysiol
; 116(8): 1967-74, 2005 Aug.
Article
en En
| MEDLINE
| ID: mdl-16000257
ABSTRACT
OBJECTIVE:
The objective of this work was to ascertain if sensory gating can be demonstrated within the human medial temporal lobe.METHODS:
Eight patients with intractable epilepsy with depth electrodes implanted in the medial temporal lobe for pre-surgery evaluation underwent evoked response recording to auditory paired-stimuli (S1-S2). Each of the eight subjects had a diagnosis of left medial temporal lobe epilepsy (MTLE).RESULTS:
Data from the non-focal right hippocampi revealed a large negative response on S1 (starting at about 190 ms and lasting for approximately 300 ms from stimulus onset). Rhinal region recordings revealed a positive response (starting at about 240 ms with a rapid incline, followed by a long-lasting decline). A significant attenuation of both responses to S2 stimuli was observed.CONCLUSIONS:
Data are suggestive of an involvement of the human medial temporal lobe in the processing of simple auditory information which occurs in a time frame later than the neocortical auditory evoked components. The exact role of these anatomical structures in the sensory gating process remains to be defined.SIGNIFICANCE:
This study provides the first evidence of an activation of the rhinal cortex after simple auditory stimulation and provides new evidence that the activation of the medial temporal lobe structures occurs at a later stage than that of the neocortex.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Percepción Auditiva
/
Lóbulo Temporal
/
Potenciales Evocados Auditivos
/
Hipocampo
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Asunto de la revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos