Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function.
J Neurosci
; 25(29): 6836-44, 2005 Jul 20.
Article
en En
| MEDLINE
| ID: mdl-16033893
ABSTRACT
Cyclin-dependent kinase inhibitors (Cdkis) influence both cell-cycle progression and differentiation of neural cells. However, the precise roles of Cdkis in coordinating formation of neurons and glia and the mechanisms that regulate expression of genes that encode Cdkis in the vertebrate CNS remain unknown. Here, we report that, in zebrafish, expression of the Cdki gene cyclin-dependent kinase inhibitor 1c (cdkn1c), a p57 homolog, is negatively regulated by Delta-Notch signaling and that Cdkn1c function is required for neural plate cells to stop dividing and differentiate as neurons on schedule, even in the absence of Notch signaling activity. Furthermore, Cdkn1c function is required for specification of oligodendrocytes from ventral spinal cord precursors. We propose that levels of cdkn1c expression are an important factor in regulating neural development high levels of Cdkn1c promote cell-cycle exit and neuronal development, whereas, during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch activity, are specified for oligodendrocyte fate.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pez Cebra
/
Oligodendroglía
/
Proteínas de Homeodominio
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Proteínas de Pez Cebra
/
Inhibidor p57 de las Quinasas Dependientes de la Ciclina
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Receptor Notch1
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Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos