Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection.
Biochem Biophys Res Commun
; 335(2): 584-9, 2005 Sep 23.
Article
en En
| MEDLINE
| ID: mdl-16091286
ABSTRACT
Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-beta plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-alpha4 can be induced independently of IFN-beta. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-beta.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interferón Tipo I
/
Transformación Celular Viral
/
Fibroblastos
Límite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2005
Tipo del documento:
Article
País de afiliación:
Alemania