[The hypoglycemic effects of crude polysaccharides extract from Momordica charantia in mice].
Wei Sheng Yan Jiu
; 34(3): 361-3, 2005 May.
Article
en Zh
| MEDLINE
| ID: mdl-16111053
ABSTRACT
OBJECTIVE:
In order to study the hypoglycemic effects of crude polysaccharides extract from Momordica charantia in normal and diabetic mice.METHODS:
Oral glucose tolerance test was carried out in 24 normal mice, CPS was orally administered in experiment group at 1 g/kg BW. 80 diabetic mice (type 1 and type 2 diabetic model) were divided into two groups randomly, CPS was administered at ad lib and fasted condition in experiment group at 1 g/kg BW, blood glucose was measured at different time.RESULTS:
In normal mice, after administered glucose (3g/kgBW) the blood glucose level of experiment group at 0.5, 1 h was significantly lower than that of control group (16.4% and 16.5% lower than control group respectively, P < 0.05 and P < 0.01). In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h, 4h were lower than that of control group (P < 0.05 and P < 0.01 respectively).CONCLUSION:
CPS can improve OGTT in normal mice, and has significant hypoglycemic effect in two types diabetic mice.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Extractos Vegetales
/
Momordica charantia
/
Diabetes Mellitus Experimental
/
Hipoglucemiantes
Límite:
Animals
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Asunto de la revista:
SAUDE PUBLICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
China