A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses.
Nat Med
; 11(11): 1244-9, 2005 Nov.
Article
en En
| MEDLINE
| ID: mdl-16227991
ABSTRACT
Graft-versus-leukemia (GVL) response after allogeneic bone marrow transplantation (BMT) represents one of the most potent forms of immunotherapy against malignant diseases. Antigen-presenting cells (APCs) are crucial for the induction of graft-versus-host disease (GVHD), the most serious complication of allogeneic BMT, but their role in GVL responses is unclear. Using a series of clinically relevant mouse GVL tumor models, we found that APCs and alloantigen expression on tumors are crucial for GVL. Moreover, APCs of host origin predominated in GVL responses although donor APCs contributed as the acuity of tumor burden decreased.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Efecto Injerto vs Leucemia
/
Isoantígenos
/
Células Presentadoras de Antígenos
Límite:
Animals
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Estados Unidos