Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 415-8, 2005.
Article
en En
| MEDLINE
| ID: mdl-16247961
ABSTRACT
In an attempt to improve the AzA selectivity of the 2-(aryl)alkylthio derivatives of adenosine, we planned the synthesis of the corresponding derivatives of the 5-N-ethylcarboxamidoadenosine (NECA). For this purpose, we designed the synthesis of 2-mercapto-NECA to be pursued by means of an opening-closure method We obtained the open AICAR analog; however, ring closure efforts failed to give the desired compound. The newly synthesized AICAR derivative could potentially be endowed with antiviral or antitumoral activity.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ribonucleótidos
/
Aminoimidazol Carboxamida
/
Antimetabolitos
Idioma:
En
Revista:
Nucleosides Nucleotides Nucleic Acids
Asunto de la revista:
BIOQUIMICA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Italia