[Severe hyperhomocysteinemia revealing homocystinuria in two young adults with mild phenotype]. / Hyperhomocystéinémie sévère révélant une homocystinurie chez deux jeunes adultes présentant un phénotype peu marqué
Rev Med Interne
; 27(2): 140-3, 2006 Feb.
Article
en Fr
| MEDLINE
| ID: mdl-16298022
ABSTRACT
INTRODUCTION:
To the request of total plasma homocysteine determination in the investigation of vascular disease, diagnosis of homocystinuria in young adult patients with mild phenotype is not so rare. EXEGESIS A 26-year-old man developed embolic cerebral infarction and a 22-year-old woman presented a right renal venous thrombosis one week after delivery. In each case, high concentration of total plasma homocysteine was first found and plasma and urinary amino acids analysis later on directed the diagnosis towards homocystinuria. Finally, reduced skin fibroblast cystathionine beta-synthase activity confirmed the diagnosis of homocystinuria.CONCLUSION:
Total plasma homocysteine determination must be determined for screening for hyperhomocysteinemia in young adults with venous thromboembolism without characteristic phenotypic features of homocystinuria.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hiperhomocisteinemia
/
Homocistinuria
Tipo de estudio:
Etiology_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Fr
Revista:
Rev Med Interne
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia