Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo.
J Bacteriol
; 188(3): 1175-9, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16428423
ABSTRACT
In Salmonella enterica, the isc operon contains genes necessary for the synthesis of Fe-S clusters and strains lacking this operon have severe defects in a variety of cellular processes. Other cellular loci that impact Fe-S cluster synthesis to a lesser extent have been described. The cyaY locus encodes a frataxin homolog, and it is shown here that lesions in this locus affect Fe-S cluster metabolism. When present in combination with other lesions, mutations in cyaY can result in a strain with more severe defects than those lacking the isc locus.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Salmonella enterica
/
Proteínas de Unión a Hierro
/
Proteínas Hierro-Azufre
Idioma:
En
Revista:
J Bacteriol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos