Differences in fertility by HIV serostatus and adjusted HIV prevalence data from an antenatal clinic in northern Uganda.
Trop Med Int Health
; 11(2): 182-7, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16451342
ABSTRACT
OBJECTIVES:
To estimate differences in fertility by HIV serostatus and to validate an adjustment method for estimating the HIV prevalence in the general female population using data from an antenatal clinic.METHODS:
We used Cox regression models to retrospectively estimate the age-specific relative fertility (RF) of HIV-positive compared to HIV-negative women among 3314 antenatal clinic attenders in northern Uganda. RF and the age distribution of women in the general female population were used to extrapolate the antenatal clinic-based HIV prevalence. This procedure was indirectly validated by comparing the adjusted estimate with those based on standard adjustment factors derived from general female populations in Uganda and Tanzania.RESULTS:
HIV-positive women reported a lower fertility than HIV-negative women [age-adjusted RF=0.83, 95% confidence interval (CI) 0.75-0.93]. Except for girls aged 15-19 (RF=0.96, 95% CI 0.74-1.24) HIV-positive women in all age groups were less fertile (20-24 year RF=0.83, 95% CI 0.67-1.01; 25-29 years RF=0.79, 95% CI 0.62-1.00; 30-49 year RF=0.79, 95% CI 0.65-0.96]. Adjusting the antenatal clinic-based HIV prevalence (11.6%) for these differences yields a higher estimate (13.8%) that is lower than those based on standard adjustment factors derived from general female populations (from 14.6% to 17.7%).CONCLUSIONS:
The age-specific pattern of differential fertility by HIV serostatus derived from antenatal clinic data is consistent with findings from population-based studies conducted in Africa. However, differences in fertility between HIV positive and HIV-negative clients underestimate those in the general female population yielding inaccurate estimates when used to extrapolate the HIV prevalence.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Fertilidad
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
País/Región como asunto:
Africa
Idioma:
En
Revista:
Trop Med Int Health
Asunto de la revista:
MEDICINA TROPICAL
/
SAUDE PUBLICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia