Cervico-vaginal foetal fibronectin: a predictor of cervical response at pre-induction cervical ripening.
West Afr J Med
; 24(4): 334-7, 2005.
Article
en En
| MEDLINE
| ID: mdl-16483052
ABSTRACT
CONTEXT Not all pregnant women with an "unripe" cervix can be successfully ripened by the cervical ripening agents; therefore tests with predictive information are justified. OBJECTIVES:
To examine the effect of the presence of foetal fibronectin (FFN) in the cervico-vaginal secretions on pre-induction cervical ripening with either intravaginal Misoprostol or transcervical Foley catheter.METHODOLOGY:
Twenty (20) patients managed at a tertiary health institution in South-western Nigeria between March and May 2003 were randomised for cervical ripening by either intravaginal Misoprostol or Transcervical Foley catheters. Cervico-vaginal secretions were assessed for presence of FFN with Foetal Fibronectin Enzyme Immunoassay Kit (Adeza Corp.) prior to commencement of cervical ripening. MAIN OUTCOMEMEASURES:
FFN status, Pre-ripening and Pre-induction modified Bishop scores and duration of cervical ripening.RESULTS:
Ten of the fifteen patients with positive membrane immunoassay for FFN achieved ripened cervix (modified Bishop score > or = 6) within 6 - 12 hours of exposure to the agents of cervical ripening. In the FFN negative group, only 2 of the five patients achieved ripe cervix within the >12 - 18 hours period, the rest being in the >18 - 24 hours period.CONCLUSION:
Foetal fibronectin test may offer useful predictive information prior to institution of processes of cervical ripening in patients with unfavourable cervices.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vagina
/
Abortivos no Esteroideos
/
Glicoproteínas
/
Cuello del Útero
/
Fibronectinas
/
Misoprostol
/
Maduración Cervical
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
West Afr J Med
Año:
2005
Tipo del documento:
Article
País de afiliación:
Nigeria