Journey through the thymus: stromal guides for T-cell development and selection.
Nat Rev Immunol
; 6(2): 127-35, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16491137
ABSTRACT
Lympho-stromal interactions in multiple microenvironments within the thymus have a crucial role in the regulation of T-cell development and selection. Recent studies have implicated that chemokines that are produced by thymic stromal cells have a pivotal role in positioning developing T cells within the thymus. In this Review, I discuss the importance of stroma-derived chemokines in guiding the traffic of developing thymocytes, with an emphasis on the processes of cortex-to-medulla migration and T-cell-repertoire selection, including central tolerance.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timo
/
Linfocitos T
/
Comunicación Celular
/
Diferenciación Celular
/
Movimiento Celular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón