Modulatory effects of hypocretin-1/orexin-A with glutamate and gamma-aminobutyric acid on freshly isolated pyramidal neurons from the rat prefrontal cortex.
Neurosci Lett
; 399(1-2): 101-5, 2006 May 15.
Article
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| MEDLINE
| ID: mdl-16495001
ABSTRACT
It is widely known that hypocretins are essential for the regulation of wakefulness. Our recent reports have found that hypocretin-1 shows a direct postsynaptic excitatory effect on rat prefrontal cortex (PFC) pyramidal neurons. It remains unclear whether hypocretin-1 may interact with two classical neurotransmitter systems, glutamate and gamma-aminobutyric acid (GABA) in rat PFC. For this reason, we here investigated the modulatory actions of hypocretin-1 with these two transmitters on freshly isolated PFC pyramidal neurons using whole-cell patch-clamp recordings. We found that coadministration of hypocretin-1 and glutamate showed a synergistic effect on the recorded cells, and hypocretin-1 could excite the neurons even if GABA was present. Thus, our data suggest that there may be hypocretin-glutamate and hypocretin-GABA interactions in the PFC.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neuropéptidos
/
Células Piramidales
/
Ácido Glutámico
/
Péptidos y Proteínas de Señalización Intracelular
/
Lóbulo Frontal
/
Ácido gamma-Aminobutírico
Límite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Año:
2006
Tipo del documento:
Article
País de afiliación:
China