Experimental axonopathy induced by immunization with Campylobacter jejuni lipopolysaccharide from a patient with Guillain-Barré syndrome.
J Neuroimmunol
; 174(1-2): 12-20, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16516981
ABSTRACT
New Zealand white rabbits were immunized with a lipopolysaccharide (LPS) extracted from a Campylobacter jejuni HS19 strain isolated from a GBS patient expressing GM1 and GD1a-like epitopes, Freund's adjuvant (group I) and Freund's adjuvant plus keyhole lympet hemocyanin (KLH) (group II). Both groups showed high titers of anti-LPS and anti-GM1 and lower titers of anti-GD1b and anti-GD1a antibodies. Weakness and axonal degeneration in sciatic nerves was detected in 1/11 of group I and 6/7 of group II. This model replicates, at least in part, the pathogenetic process hypothesized in the human axonal GBS with antiganglioside antibodies post C. jejuni infection and indicates that KLH plays an additional role in neuropathy induction.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polirradiculoneuropatía
/
Lipopolisacáridos
/
Campylobacter jejuni
/
Síndrome de Guillain-Barré
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia