OPG, RANK-L, bone metabolism, and BMD in patients on peritoneal dialysis and hemodialysis.
Clin Biochem
; 39(6): 617-22, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16530745
ABSTRACT
OBJECTIVES:
Bone turnover is regulated locally by osteoprotegerin (OPG) and receptor activator of NFkappaB ligand (RANK-L); it is not known how the circulating concentrations of these cytokines reflect renal osteodystrophy.METHODS:
We measured serum OPG, RANK-L, parathyroid hormone (iPTH), collagen C-terminal cross-linked telopeptide (betaCrossLaps), and bone densitometry (BMD) in 79 patients with end-stage renal disease (ESRF) undergoing dialysis. A hand X-ray of these patients was also analyzed. Controls were 65 healthy subjects.RESULTS:
ESRF patients had high OPG and RANK-L levels; RANK-L was higher in hemodialysis than in peritoneal dialysis. OPG and RANK-L did not depend on iPTH. The bone markers were significantly increased and correlated with serum iPTH, but not with OPG or RANK-L; neither OPG nor RANK-L correlated significantly with BMD. OPG was significantly higher in patients with acro-osteolysis.CONCLUSIONS:
OPG and RANK-L serum concentrations do not strongly reflect bone status in ESRF. However, OPG was significantly higher in patients with acro-osteolysis.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Huesos
/
Glicoproteínas de Membrana
/
Glicoproteínas
/
Proteínas Portadoras
/
Densidad Ósea
/
Diálisis Renal
/
Diálisis Peritoneal
/
Receptores del Factor de Necrosis Tumoral
/
Receptores Citoplasmáticos y Nucleares
/
Fallo Renal Crónico
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Biochem
Año:
2006
Tipo del documento:
Article
País de afiliación:
Bélgica