Human sebaceous tumors harbor inactivating mutations in LEF1.
Nat Med
; 12(4): 395-7, 2006 Apr.
Article
en En
| MEDLINE
| ID: mdl-16565724
ABSTRACT
We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Sebáceas
/
Activación Transcripcional
/
Sustitución de Aminoácidos
/
Beta Catenina
/
Factor de Unión 1 al Potenciador Linfoide
Límite:
Humans
Idioma:
En
Revista:
Nat Med
Asunto de la revista:
BIOLOGIA MOLECULAR
/
MEDICINA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido