Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent.
Arzneimittelforschung
; 56(2A): 136-51, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16570822
ABSTRACT
The arylphosphoramidate derivative of stavudine (STV, d4T, 2,3'-didehydro-3'-deoxythymidine, CAS 3056-17-5), stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6), is a novel anti-HIV agent. STAMP was prepared under current Good Manufacturing Practice (cGMP) conditions on the scale of kilograms. Solid STAMP was subsequently formulated as a capsule under GMP conditions for oral administration.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Timidina Monofosfato
/
Estavudina
/
Fármacos Anti-VIH
Idioma:
En
Revista:
Arzneimittelforschung
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos