Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children.
Environ Health Perspect
; 114(4): 603-9, 2006 Apr.
Article
en En
| MEDLINE
| ID: mdl-16581553
ABSTRACT
Urinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted 0.69 vs. 0.34 micromol/mol creatinine, p < 0.001; unadjusted 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 micromol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Policíclicos
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Pirenos
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Biomarcadores
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Exposición a Riesgos Ambientales
Tipo de estudio:
Observational_studies
Límite:
Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Environ Health Perspect
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos