Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice.
Genes Chromosomes Cancer
; 45(7): 668-75, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16586494
ABSTRACT
The tumor suppressor TP53 is mutated in approximately 70% of Li-Fraumeni syndrome (LFS) families; however, other genes may lead to the predisposition to tumors in other families. We developed a mouse model to search for other tumor suppressors that may be involved in the syndrome. Inbred CE/J mice, which succumb to multiple types of tumors similar to those found in LFS, were crossed with the Trp53-null 129-Trp53tm1Tyj mouse. We monitored the tumor onset and type and found a significant earlier tumor onset in the CE/J129-Trp53tm1Tyj mice compared with 129-Trp53tm1Tyj mice with a Trp53-null allele. Additionally, in CE/J129-Trp53tm1Tyj-Trp53+/- mice, the tumors metastasize, which does not occur in other strains of mice. Using simple-sequence length polymorphism analysis for loss of heterozygosity in tumors, we identified a putative tumor suppressor locus within 1 cM on mouse chromosome 11, which encompasses 12 mapped genes.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Genes Supresores de Tumor
/
Mapeo Cromosómico
/
Síndrome de Li-Fraumeni
/
Metástasis de la Neoplasia
Límite:
Animals
Idioma:
En
Revista:
Genes Chromosomes Cancer
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos