Versatile routes toward functional, water-soluble nanoparticles via trifluoroethylester-PEG-thiol ligands.
Langmuir
; 22(9): 4319-26, 2006 Apr 25.
Article
en En
| MEDLINE
| ID: mdl-16618182
ABSTRACT
This paper reports the synthesis of a trifluoroethylester-PEG-thiol ligand (TFEE-PEG-SH) and its use to create water-soluble, chemically functional Au metal and FePt magnetic nanoparticles. The trifluoroethylester terminus facilitates attachment of any primary-amine-containing molecule via amide bond formation at room temperature without the use of coupling agents. Three possible routes of nanoparticle functionalization are demonstrated synthesis of Au nanoparticles in the presence of functionalized R-PEG-SH; ligand-exchange of R-PEG-SH onto both Au and FePt nanoparticles; and exchange of TFEE-PEG-SH onto Au nanoparticles followed by subsequent amide condensation. A series of primary-amine-containing molecules, including biotin and fluorescamine, are easily attached to the water-soluble particles, and the resulting materials are characterized by NMR, UV-visible absorption, and emission spectroscopies.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Langmuir
Asunto de la revista:
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos