Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.
Mol Cell Biol
; 11(3): 1745-50, 1991 Mar.
Article
en En
| MEDLINE
| ID: mdl-1671710
ABSTRACT
The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Transformación Celular Neoplásica
/
Proteínas Oncogénicas Virales
/
Proteínas Proto-Oncogénicas
Límite:
Animals
Idioma:
En
Revista:
Mol Cell Biol
Año:
1991
Tipo del documento:
Article