Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia.
Acta Physiol (Oxf)
; 187(1-2): 75-85, 2006.
Article
en En
| MEDLINE
| ID: mdl-16734744
ABSTRACT
Phospholipase A2 (PLA2) activity is increased in mammalian cells in response to numerous stimuli such as osmotic challenge, oxidative stress and exposure to allergens. The increased PLA2 activity is seen as an increased release of free, polyunsaturated fatty acids, e.g. arachidonic acid and membrane-bound lysophospholipids. Even though arachidonic acid acts as a second messenger in its own most mammalian cells seem to rely on oxidation of the fatty acid into highly potent second messengers via, e.g. cytochrome P450, the cyclo-oxygenase, or the lipoxygenase systems for downstream signalling. Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fosfolipasas A
/
Estrés Fisiológico
/
Sistemas de Mensajero Secundario
/
Células Musculares
/
Isoenzimas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Acta Physiol (Oxf)
Asunto de la revista:
FISIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Dinamarca