Mutations in the DNA mismatch repair gene MLH1 associated with early-onset colon cancer.
J Pediatr
; 148(6): 837-9, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16769400
ABSTRACT
Hereditary nonpolyposis colon cancer (HNPCC) is an autosomal dominant disorder characterized by the predisposition to develop a number of cancers, especially colorectal cancer (CRC). We present a HNPCC family with CRC at age 12 years. Our observations suggest that the germline mutation of the both copies of the MLH1 gene may play a role in the early onset of CRC.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Colon Sigmoide
/
Proteínas Nucleares
/
Adenocarcinoma
/
Proteínas Portadoras
/
Neoplasias Colorrectales Hereditarias sin Poliposis
/
Mutación de Línea Germinal
/
Reparación del ADN
Tipo de estudio:
Risk_factors_studies
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
J Pediatr
Año:
2006
Tipo del documento:
Article
País de afiliación:
España