TRH therapy in a patient with juvenile Alexander disease.
Brain Dev
; 28(10): 663-7, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16774812
ABSTRACT
Alexander disease is a rare disorder of the central nervous system caused by a de novo mutation in the glial fibrillary acidic protein (GFAP) gene. Unlike the much more common infantile form, the juvenile form is slowly progressive with bulbar, pyramidal and cerebellar signs. Herein, we report a 9-year old Japanese girl suffering from frequent vomiting, slurred speech and truncal ataxia. Juvenile Alexander disease was diagnosed by genetic analysis, which detected a novel GFAP mutation, D360V. We also describe our clinical success in treating this patient with thyrotropin releasing hormone (TRH).
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Tirotropina
/
Enfermedad de Alexander
Límite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Brain Dev
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón