Contributions of sigB and sarA to distinct multiple antimicrobial resistance mechanisms of Staphylococcus aureus.
Int J Antimicrob Agents
; 28(1): 54-61, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16777384
ABSTRACT
Multiple antimicrobial resistance in Staphylococcus aureus can result from mutations leading to reduced susceptibility to Pine oil-based cleaners (PS(RS)) as well as following growth with the non-steroidal anti-inflammatory salicylate. We now define the contributions of the alternative sigma factor (sigB) and staphylococcal accessory regulator (sarA) to these mechanisms. We conclude that sarA plays a more prominent role than sigB in overall intrinsic multiple antimicrobial resistance. Both genes have similar effects on intrinsic vancomycin resistance, and the salicylate-inducible mechanism is not sigB- or sarA-dependent. Furthermore, analyses determined that altered expression of sigB and sarA is not responsible for the salicylate-inducible mechanism, and sarA upregulation is associated with the PS(RS) phenotype.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor sigma
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Staphylococcus aureus
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Proteínas Bacterianas
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Farmacorresistencia Microbiana
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Transactivadores
Idioma:
En
Revista:
Int J Antimicrob Agents
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos