Association of cytokines, neurological disability, and disease duration in HAM/TSP patients.
Arq Neuropsiquiatr
; 64(2A): 217-21, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16791359
ABSTRACT
OBJECTIVE:
To identify clinical and immunological markers associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP).METHOD:
237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osames Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals.RESULTS:
37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-gamma were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers.CONCLUSION:
This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a progressive behavior of HAM/TSP. This study also shows that IFN-gamma in PBMC supernatants are markers of HAM/TSP.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trastornos Psicomotores
/
Leucocitos Mononucleares
/
Virus Linfotrópico T Tipo 1 Humano
/
Paraparesia Espástica Tropical
/
Citocinas
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arq Neuropsiquiatr
Año:
2006
Tipo del documento:
Article
País de afiliación:
Brasil