Interstitial radiation therapy for early-stage nasal vestibule cancer: a continuing quest for optimal tumor control and cosmesis.
Int J Radiat Oncol Biol Phys
; 66(1): 160-9, 2006 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-16839706
ABSTRACT
INTRODUCTION:
This article reports on the effectiveness, cosmetic outcome, and costs of interstitial high-dose-rate (HDR) brachytherapy for early-stage cancer of the nasal vestibule (NV) proper and/or columella high-dose-rate (HDR). METHODS AND MATERIALS Tumor control, survival, cosmetic outcome, functional results, and costs were established in 64 T1/T2N0 nasal vestibule cancers treated from 1991-2005 by fractionated interstitial radiation therapy (IRT) only. Total dose is 44 Gy 2 fractions of 3 Gy per day, 6-hour interval, first and last fraction 4 Gy. Cosmesis is noted in the chart by the medical doctor during follow-up, by the patient (visual analog scale), and by a panel. Finally, full hospital costs are computed.RESULTS:
A local relapse-free survival rate of 92% at 5 years was obtained. Four local failures were observed; all four patients were salvaged. The neck was not treated electively; no neck recurrence in follow-up was seen. Excellent cosmetic and functional results were observed. With 10 days admission for full treatment, hospital costs amounted to euro5772 (7044 US dollars).CONCLUSION:
Excellent tumor control, cosmesis, and function of nasal airway passage can be achieved when HDR-IRT for T1/T2N0 NV cancers is used. For the more advanced cancers (Wang classification T3 tumor stage), we elect to treat by local excision followed by a reconstructive procedure. The costs, admission to hospital inclusive, for treatment by HDR-IRT amounts to euro5772 (7044 US dollars). This contrasts substantially with the full hospital costs when NV cancers are treated by plastic reconstructive surgery, being on average threefold as expensive.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Braquiterapia
/
Carcinoma Basocelular
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Carcinoma de Células Escamosas
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Neoplasias Nasales
/
Estética
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Año:
2006
Tipo del documento:
Article
País de afiliación:
Países Bajos