Epithelial sodium channel in planar lipid bilayers.
Methods Mol Biol
; 337: 89-99, 2006.
Article
en En
| MEDLINE
| ID: mdl-16929941
ABSTRACT
Amiloride-sensitive Na+ channels belong to the epithelial Na+ channel (ENaC)-degenerin superfamily of ion channels. In addition to their key role in sodium handling, they serve diverse functions in many tissues. Improper functioning of ENaC has been implicated in several diseases, including salt-sensitive hypertension (Liddle's syndrome), salt-wasting syndrome (pseudohypoaldosteronism type I), pulmonary edema, and cystic fibrosis. We have utilized planar lipid bilayers, a well-defined system that allows simultaneous control of "internal" and "external" solutions, to study ENaCs.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Canales Epiteliales de Sodio
/
Membrana Dobles de Lípidos
Límite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos