Deconstructing the molecular portrait of basal-like breast cancer.
Trends Mol Med
; 12(11): 537-44, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-17011236
ABSTRACT
Gene-expression profiling has revealed several molecular subtypes of breast cancer, which differ in their pathobiology and clinical outcomes. Basal-like tumors are a newly recognized subtype of breast cancer, which express genes that are characteristic of basal epithelial cells, such as the basal cytokeratins, and are associated with poor relapse-free and overall survival. However, the genetic and epigenetic alterations that are responsible for the biologically aggressive phenotype of these estrogen receptor-negative and HER2/ErbB2-negative tumors are not well understood, thereby hindering efforts to develop targeted therapies. Here, we focus on new insights into the molecular pathogenesis of basal-like breast cancer and explore how these discoveries might impact the treatment of these poor-prognosis tumors.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Biomarcadores de Tumor
/
Regulación Neoplásica de la Expresión Génica
/
Neoplasias Basocelulares
/
Receptor ErbB-2
/
Proteína BRCA1
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Trends Mol Med
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos